In the year 2000, cancer was the leading cause of death in only two states. Recently the Centers for Disease Control and Prevention’s 2014 report was released, showing that cancer is now competing with heart disease to be the leading cause of death in the U.S. In fact, it is now the leading cause of death in 22 states. Here’s a ranked list of the states with the highest rates of cancer death according to the 2014 report. Rates are out of every 100,000 people.